TABLE VI.

Mobility and exercise for individuals with Angelman syndrome, late-adolescence through adulthood

	Full Cohort % (n)	Female odds ratio	21–25y odds ratio	26–30y odds ratio	31–50y odds ratio	UBE3A odds ratio	UPD odds ratio
Mobility
Walks independently	68% (85)	4.544*	1.110	2.290	0.251	0.500	3.500
Side arm assist	22% (85)	0.454	0.986	0.810	2.341	1.843	0.439
Non-ambulatory	4% (85)	0.433	1.203	IS (0%, 17)	2.331	3.929	IS (0%, 8)
Walks in the home
Always	93% (109)	8.581	1.016	IS (100%, 23)	0.306	0.706	IS (100%, 10)
Almost never (<10%)	7% (109)	0.117	0.985	IS (0%, 23)	3.272	1.417	IS (0%, 10)
Walks in the community
Always	38% (109)	1.789	1.207	1.123	0.779	1.667
Almost never (<10%)	18% (109)	0.329*	1.375	IS (0%, 23	1.968	1.224	IS (0%, 10)
Maximum distance
< 50–100 yards	41% (108)	0.714	1.992	2.220	2.824	1.961	0.294
1/4 – 1 mile	35% (108)	1.426	0.479	0.682	0.455	0.249	1.160
No clear distance limit	25% (108)	0.904	0.923	0.508	0.607	1.564	4.692*
Walking distance limited by
Behavior	22% (101)	0.934	0.792	1.694	0.610	IS (0%, 8)	0.671
Physical symptoms	43% (101)	1.744	1.380	1.126	1.533	2.222	0.571
Exercise
Able to run	35% (108)	1.953	0.683	0.685	0.753	1.739	1.449
Swimming	90% (109)	0.736	IS (100%, 29)	0.070	0.075*	0.836	0.418
Shallow water or with float	77% (109)	1.073	0.986	0.386	0.452	0.552	0.414
Deep water without a float	13% (109)	0.723	1.228	0.553	0.390	2.063	1.806
Horseback riding
Current routine	17% (84)	1.169	0.493	0.295	0.714	1.636	1.432
Lifetime	77% (84)	0.885	0.765	0.686	0.404	0.345	1.103
Positive experience	58% (84)	1.005	0.876	0.750	0.636	0.718	0.897
Adaptive bike lifetime
Current routine	33% (84)	0.750	0.480	0.135	0.302	1.042	3.125
Lifetime	77% (84)	0.882	1.411	1.038	0.612	0.902	4.059
Positive experience	60% (84)	0.952	1.576	0.649	0.425	0.718	8.077

Age sub-groups compared with the 16–20y cohort. Genotype sub-groups compared with the Del cohort.

^*statistically significant odds ratio (α = 0.05). IS: infinite solution (%, n).