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. Author manuscript; available in PMC: 2017 Jul 30.
Published in final edited form as: Am J Med Genet A. 2014 Nov 26;167A(2):331–344. doi: 10.1002/ajmg.a.36864

TABLE VI.

Mobility and exercise for individuals with Angelman syndrome, late-adolescence through adulthood

Full Cohort
% (n)
Female
odds ratio
21–25y
odds ratio
26–30y
odds ratio
31–50y
odds ratio
UBE3A
odds ratio
UPD
odds ratio

Mobility
 Walks independently 68% (85) 4.544* 1.110 2.290 0.251 0.500 3.500
 Side arm assist 22% (85) 0.454 0.986 0.810 2.341 1.843 0.439
 Non-ambulatory 4% (85) 0.433 1.203 IS (0%, 17) 2.331 3.929 IS (0%, 8)
 Walks in the home
  Always 93% (109) 8.581 1.016 IS (100%, 23) 0.306 0.706 IS (100%, 10)
  Almost never (<10%) 7% (109) 0.117 0.985 IS (0%, 23) 3.272 1.417 IS (0%, 10)
 Walks in the community
  Always 38% (109) 1.789 1.207 1.123 0.779 1.667
  Almost never (<10%) 18% (109) 0.329* 1.375 IS (0%, 23 1.968 1.224 IS (0%, 10)
 Maximum distance
  < 50–100 yards 41% (108) 0.714 1.992 2.220 2.824 1.961 0.294
  1/4 – 1 mile 35% (108) 1.426 0.479 0.682 0.455 0.249 1.160
  No clear distance limit 25% (108) 0.904 0.923 0.508 0.607 1.564 4.692*
 Walking distance limited by
  Behavior 22% (101) 0.934 0.792 1.694 0.610 IS (0%, 8) 0.671
  Physical symptoms 43% (101) 1.744 1.380 1.126 1.533 2.222 0.571
Exercise
 Able to run 35% (108) 1.953 0.683 0.685 0.753 1.739 1.449
 Swimming 90% (109) 0.736 IS (100%, 29) 0.070 0.075* 0.836 0.418
  Shallow water or with float 77% (109) 1.073 0.986 0.386 0.452 0.552 0.414
  Deep water without a float 13% (109) 0.723 1.228 0.553 0.390 2.063 1.806
 Horseback riding
  Current routine 17% (84) 1.169 0.493 0.295 0.714 1.636 1.432
  Lifetime 77% (84) 0.885 0.765 0.686 0.404 0.345 1.103
  Positive experience 58% (84) 1.005 0.876 0.750 0.636 0.718 0.897
 Adaptive bike lifetime
  Current routine 33% (84) 0.750 0.480 0.135 0.302 1.042 3.125
  Lifetime 77% (84) 0.882 1.411 1.038 0.612 0.902 4.059
  Positive experience 60% (84) 0.952 1.576 0.649 0.425 0.718 8.077

Age sub-groups compared with the 16–20y cohort. Genotype sub-groups compared with the Del cohort.

*

statistically significant odds ratio (α = 0.05). IS: infinite solution (%, n).