TABLE VII.
Communication and activities of daily living for individuals with Angelman syndrome, late-adolescence through adulthood
| Full Cohort % (n) |
Female odds ratio |
21–25y odds ratio |
26–30y odds ratio |
31–50y odds ratio |
UBE3A odds ratio |
UPD odds ratio |
|
|---|---|---|---|---|---|---|---|
|
|
|||||||
| ADLs | |||||||
| Self feeds with utensils | 71% (85) | 1.443 | 1.104 | 1.724 | 1.876 | 3.500 | 3.500 |
| Continent of bowel and bladder a | |||||||
| Daytime | 39% (85) | 1.270 | 0.912 | 0.895 | 1.605 | 0.722 | 15.167* |
| Nighttime | 20% (85) | 0.603 | 0.742 | 0.815 | 1.612 | 2.381 | 7.143* |
| Communication | |||||||
| Words | 47% (109) | 1.760 | 0.757 | 0.875 | 0.561 | 5.431* | 3.621 |
| ≥5 words | 13% (109) | 3.056 | 0.339 | 1.034 | 0.310 | 2.735 | 4.102 |
| Sounds with meaning | 54% (109) | 0.621 | 0.708 | 1.343 | 1.455 | 1.895 | 3.789 |
| Signs or natural gestures | 68% (109) | 1.483 | 1.349 | 1.191 | 0.859 | 4.870 | 5.478 |
| ≥5 signs | 33% (109) | 1.447 | 1.258 | 0.433 | 0.220 | 13.767* | 35.400* |
| Photos | 43% (109) | 0.692 | 0.813 | 0.374 | 0.286 | 1.641 | 1.969 |
| Pictures | 33% (109) | 1.001 | 1.369 | 0.122* | 0.085* | 0.595 | 3.125 |
| Voice output device or iPad | 15% (109) | 1.008 | 1.267 | 0.463 | 0.324 | IS (0%, 9) | 1.292 |
| Music extremely important | 90% (108) | 0.313 | 2.339 | 0.365 | 0.340 | 0.970 | IS (100%, 9) |
Age sub-groups compared with the 16–20y cohort. Genotype sub-groups compared with the Del cohort.
*
statistically significant odds ratio (α = 0.05).
a
consistently does not wear a diaper or pull-up. IS: infinite solution (%, n). solution, AED: anti-epileptic drugs, Tx: treatment, y: years.