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Effect of BChE-K genotype on cognitive decline in control (A and C) vs. donepezil treated (B and D) individuals at the end of the 36-months trial. Box plot of the mean changes of MMSE (A and B) and CDR-SB (C and D) by genotype and by treatment groups. A significant association is found between BChE K–genotype and response to donepezil (B and D).
