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. Author manuscript; available in PMC: 2018 Apr 28.
Published in final edited form as: Curr Opin Microbiol. 2017 Apr 28;36:118–127. doi: 10.1016/j.mib.2017.03.013

Figure 4. Selective substrate degradation from a hierarchical assembly of adaptors.

Figure 4

In Caulobacter crescentus, the degree of assembly of adaptors dictates which substrates are degraded. Substrate 1 is degraded by an active ClpXP following binding of a dephosphorylated CpdR adaptor, which primes ClpXP for selective substrate recognition. Substrate 2 is bound by the RcdA adaptor, which delivers cargos to a CpdR-activated protease and restricts degradation of substrate 1. Finally, the PopA adaptor can bind RcdA to form a complex that delivers Substrate 3. The hierarchical assembly of these adaptors during the Caulobacter cell cycle leads to ordered, progressive degradation of key regulators.