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. 2017 Jul 31;8:160. doi: 10.1038/s41467-017-00233-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The active site of MdcD–MdcE. a Simulated-annealing omit F _o−F _c electron density map at 3.0 Å resolution for CoA in the active site of MdcD–MdcE, contoured at 3σ. b Residues in the active site of MdcD–MdcE. Interactions between CoA (gray) and MdcD–MdcE are shown. Hydrogen-bonding interactions are indicated with dashed lines (red). The possible binding site for the malonyl group is indicated with the red arrow. c MdcD–MdcE demonstrates cooperative behavior towards malonyl-CoA. The initial velocity data are fitted to the Hill equation to obtain the kinetic parameters (blue curve). The Michael–Menten equation does not produce as good a fit to the data (red curve). Data from one representative set of experiments are shown