Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 31;8:159. doi: 10.1038/s41467-017-00188-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Hel2-dependent ubiquitination was required for a triggering step of RQC pathway. a An E3 ubiquitin ligase Hel2 was required for not only translation arrest, but also the production of arrest products. b The ubiquitination activity of Rqt1 was crucial for induction of RQC. c The distribution of Rqt1 proteins in polysome profiles. d The ubiquitinated proteins in ribosome depended on Hel2/Rqt1 and Ubc4. Arrowed proteins were identified by mass spectrometry. e K212 residue of uS3 and K6 and K8 residues of uS10 were ubiquitination sites of them. f Hel2-dependent ubiquitination of uS10-K6/8 was crucial for induction of RQC pathway