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. 2017 Jul 31;8:867. doi: 10.3389/fimmu.2017.00867

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Copyright © 2017 Beirnaert, Desmyter, Spinelli, Lauwereys, Aarden, Dreier, Loris, Silence, Pollet, Cambillau and de Haard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The binding sites of the three Nanobodies™ on tumor necrosis factor (TNF) trimer. (A) Complex TNF–VHH#1. (B) Complex TNF–VHH#2. (C) Complex TNF–VHH#3. TNF-monomer surfaces are colored orange, violet, and yellow. The residues of the Nanobodies™ in interaction with TNF are displayed as blue surfaces.