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The binding sites of the three Nanobodies™ and of the extracellular domain of the tumor necrosis factor (TNF) receptor p55 (TNFR1) mapped on TNF. (A) VHH#1, VHH#2, and TNFR1. (B) VHH#3 and TNFR1. The TNF trimer surface is colored orange. The TNFR1 surface of a unique monomer is colored yellow. Surfaces of VHH#1, VHH#2, and VHH#3 are colored red, green, and blue, respectively. Note the superposition of the Nanobodies’ surfaces with those of TNFR1.
