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. 2017 Jul 31;8:1447. doi: 10.3389/fmicb.2017.01447

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Copyright © 2017 de la Campa, Ferrándiz, Martín-Galiano, García and Tirado-Vélez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evidence for conservation of UP and DOWN domains in S. pneumoniae. Relationship between the gene-lack index and gene expression (fluorescent units, FU) in S. pneumoniae R6 as detected in high density microarrays. A total of 12 genome sequences (from 11 clinical isolates and R6) were analyzed. Genes of clinical isolates were considered equivalent to those of R6 when their products shared ≥80% similarity over ≥80% of the sequence length. An 11-gene window (about 10 kb) was contemplated.