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. 2017 Jul 31;8:895. doi: 10.3389/fimmu.2017.00895

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Copyright © 2017 Pecoraro, Nigro, Polito, Monaco, Scudiero, Mormile, Cesoni Marcelli, Capasso, Habetswallner, Genovese, Daniele and Spadaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adiponectin (Acrp30) levels strongly increase after Ig replacement therapy in common variable immunodeficiency (CVID) treatment-naïve patients. Acrp30 and high molecular weight oligomers in two representative CVID naïve patients P-1 and P-2 subjected to Ig replacement therapy. (A) Total Acrp30 serum levels obtained through enzyme-linked immunosorbent assay (ELISA) assay; Acrp30 oligomers distribution in each fraction obtained from fast protein liquid chromatography analysis and subjected to ELISA assays (B) and western blotting (C). The patients have been analyzed before starting treatment (naïve = 0) and during the time course post therapy (1, 7, 14, and 21 days). For other details, see Section “Materials and Methods.”