Table 2.

Examples of available definitions of organ failures used in patients with cirrhosis

Failing organ	Asian Pacific Association for the Study of the Liver organ failures definition (4, 5)	European Association for the Study of Liver-Chronic Liver failure organ failures definition (9)	North American Consortium for Study of End-stage Liver Disease organ failures definition (7)
Liver	Total bilirubin ≥5 mg/dL and INR ≥1.5	Bilirubin level of >12 mg/dL	–
Kidney	Acute Kidney Injury Network criteria	Creatinine level of ≥2.0 mg/dL or renal replacement	Need for dialysis or other forms of renal replacement therapy
Brain	West-Haven hepatic encephalopathy grade 3–4	West-Haven hepatic encephalopathy grade 3–4	West-Haven hepatic encephalopathy grade 3–4
Coagulation	INR ≥1.5	INR ≥2.5	–
Circulation	–	Use of vasopressor (terlipressin and/or catecholamines)	Presence of shock defined by mean arterial pressure <60 mm Hg or a reduction of 40 mm Hg in systolic blood pressure from baseline, despite adequate fluid resuscitation and cardiac output
Respiration		PaO2/FiO2 of ≤200 or SpO2/FiO2 of ≤214 or need for mechanical ventilation	Need for mechanical ventilation

FiO₂, fraction of inspired oxygen; INR, international normalised ratio; PaO₂, partial pressure of arterial oxygen; SpO₂, pulse oximetric saturation.