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. 2016 Jan 5;66(3):399–410. doi: 10.1136/gutjnl-2015-310888

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This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow chart of study identification process. *One study provided sufficient information for statistical extraction; however, interpretation of data was not possible due to inconsistent definition of protein 53 (p53) mutation status in survival analysis, in as much that p53 positive denoted a change from p53 positivity pre-radiochemotherapy to p53 negative post-chemoradiotherapy. One study only presented final survival data on loss of heterozygosity at chromosome 17q, which does not contain the tumour protein 53 (TP53) gene. AACR, American Association for Cancer Research; ASCO, American Society for Clinical Oncology; DDW, Digestive Disease Week; JCO, Journal of Clinical Oncology.