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. 2016 Jan 6;66(3):429–437. doi: 10.1136/gutjnl-2015-310283

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Gut microbiota increases hepatic steatosis and expression of genes involved in lipoprotein uptake through farnesoid X receptor (FXR). (A) Quantification of triglycerides, (B) saturated triglycerides and (C) cholesteryl esters in livers from germ-free (GF) and CONV-R wild-type and Fxr−/− male mice after 10 weeks on a high-fat diet (HFD) (n=4–9 mice per group). (D) Alanine transaminase (ALT) levels in the serum of mice after 10 weeks on a HFD (n=5–8 mice per group). (E–G) qPCR analysis of Cd36, Apoc2 and Vldlr expression in livers from mice after 10 weeks on a HFD (n=4–9 mice per group). Mean values±SEM are plotted; *p<0.05, **p<0.01, ***p<0.001 versus GF of same genotype; #significant for genotype–colonisation interaction.