Table 3. Hazard ratios of dementia during the first three years following CVD diagnosis, and more than three years following a CVD diagnosis, for total sample and stratified on genetic risk score for coronary artery disease.
| Total sample |
Stratified on CAD genetic risk score |
|||||
|---|---|---|---|---|---|---|
| 1st quartile | 2nd quartile | 3rd quartile | 4th quartile | Trend P-value | ||
| All dementia cases | n=1430 | n=392 | n=356 | n=364 | n=318 | |
| HR first 3 years after CVD | 1.92 (1.57–2.36) | 1.59 (1.05–2.41) | 1.82 (1.19–2.78) | 2.38 (1.65–3.42) | 1.91 (1.28–2.86) | <0.000001 |
| HR>3 years after CVD | 1.08 (0.92–1.26) | 1.11 (0.81–1.51) | 0.84 (0.61–1.18) | 1.34 (1.02–1.78) | 1.02 (0.74–1.40) | 0.35 |
| Alzheimer's disease cases | n=868 | n=235 | n=209 | n=211 | n=213 | |
| HR first 3 years after CVD | 1.47 (1.11–1.95) | 1.65 (0.97–2.79) | 1.36 (0.75–2.48) | 1.09 (0.56–2.12) | 1.64 (1.00–2.70) | 0.02 |
| HR>3 years after CVD | 0.84 (0.67–1.05) | 0.96 (0.63–1.49) | 0.81 (0.52–1.25) | 0.88 (0.58–1.35) | 0.71 (0.47–1.08) | 0.7 |
| Vascular dementia cases | n=312 | n=85 | n=83 | n=86 | n=58 | |
| HR first 3 years after CVD | 2.68 (1.85–3.89) | 1.30 (0.52–3.30) | 1.80 (0.77–4.18) | 5.61 (3.24–9.71) | 2.56 (1.08–6.08) | <0.000001 |
| HR>3 years after CVD | 1.35 (0.99–1.83) | 0.76 (0.37–1.57) | 1.04 (0.57–1.89) | 1.99 (1.15–3.42) | 1.92 (1.05–3.48) | 0.01 |
Abbreviations: CAD, coronary artery disease; CVD, cardiovascular disease; HR, hazard ratio.
Number of cases and hazard ratios (95% confidence intervals) of dementia/Alzheimer's disease in the presence of CVD, for the total sample and stratified by quartiles of genetic risk score for CAD. Bold numbers indicate significance. The model is adjusted for age, sex, education and diabetes during follow-up.