Table 4. Pairwise genetic overlap between Alzheimer's disease, coronary artery disease and their shared risk factors.
| Nr of genes |
Alzheimer's disease |
Coronary artery disease |
|||||
|---|---|---|---|---|---|---|---|
| Expected | Observed | P-value | Expected | Observed | P-value | ||
| Alzheimer's disease | 42 | — | — | — | 0 | 0 | 1 |
| Coronary artery disease | 54 | 0 | 0 | 1 | — | — | — |
| Type 2 diabetes | 11 | 0 | 0 | 1 | 0 | 0 | 1 |
| Body mass index | 56 | 0 | 2 | 0.04 | 0 | 0 | 1 |
| Total cholesterol | 231 | 1 | 14 | 1.03 × 10−15 | 1 | 14 | 3.02 × 10−14 |
| High-density lipoprotein | 198 | 0 | 5 | 1.33 × 10−4 | 1 | 1 | 0.46 |
| Low-density lipoprotein | 151 | 0 | 20 | 3.52 × 10−28 | 0 | 12 | 1.24 × 10−13 |
| Triglycerides | 175 | 0 | 8 | 1.28 × 10−8 | 1 | 1 | 0.41 |
| Systolic blood pressure | 15 | 0 | 0 | 1 | 0 | 1 | 0.05 |
| Diastolic blood pressure | 24 | 0 | 0 | 1 | 0 | 1 | 0.07 |
Table of the total number (Nr) of significant genes for each phenotype at P<2.84 × 10−6 out of the 17 581 genes available. For Alzheimer's disease and coronary artery disease, the expected and observed number of genes in common with risk factors, together with Fisher P-values for the observed overlap. Bold numbers indicate significance.