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. 2017 May 9;7(5):e1120. doi: 10.1038/tp.2017.80

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Hippocampal microglial cells from Poly(I:C) mice show a profoundly altered transcriptome signature. (a) Hierarchical clustering of the read counts of the differentially expressed genes between Poly(I:C) and control mice (adjusted P-value <0.01). The genes in cluster 1 were significantly downregulated in microglia from Poly(I:C) mice as compared with controls. The genes pertaining to cluster 2 were upregulated. Minocycline treatment brings the expression levels of genes in these clusters to a level similar to controls. Beside the clusters are displayed examples of biological processes associated with the genes within the clusters. (b) Empirical cumulative distribution function of the log2 fold changes of PU.1 target genes as well as non-target (expression matched) control genes. Genes targeted by PU.1 are selectively downregulated in Poly animals and minocycline treatment shifts back the expression pattern of these genes to normal levels. Kolmogorov–Smirnov two-sided test was used to calculate the P-values. Two biological replicates per group were used for the sequencing, where every replicate is a pool of microglia from the hippocampi of three mice.