Table 5. Meta-analysis results for ventricular, subcortical and intracranial volumes, comparing MDD-NSS vs MDD-SS.

Brain volume	Cohen'sd (MDD-NSS vs MDD-SS)	Std. Err.	95% CI	% Difference	P-value	Heterogeneity (i2)	# MDD-NSS	# MDD-SS
Lateral ventricles	0.060	0.076	[−0.900, 0.209]	0.78	0.43	0.00	626	441
Thalamus	0.021	0.076	[−0.128, 0.171]	0.28	0.78	0.00	621	443
Caudate	−0.014	0.076	[−0.163, 0.136]	−0.18	0.86	0.00	621	445
Putamen	0.036	0.111	[−0.181, 0.253]	0.32	0.75	46.19	601	435
Pallidum	−0.056	0.088	[−0.228, 0.116]	−0.64	0.52	18.21	604	433
Hippocampus	0.069	0.076	[−0.081, 0.219]	0.91	0.36	0.00	629	443
Amygdala	0.065	0.076	[−0.085, 0.214]	0.85	0.40	0.00	622	441
Accumbens	0.026	0.077	[−0.125, 0.178]	0.34	0.73	0.00	593	425
ICV	0.064	0.077	[−0.088, 0.215]	0.83	0.41	0.00	643	453

Abbreviations: CI, confidence interval; ICV, intracranial volume; MDD, major depressive disorder; MDD-NSS, MDD patients with no suicidal ideation/planning/attempt; MDD-SS, MDD patients with any suicidal symptom; std. err., standard error.

Age, sex, scan centre and ICV were used as covariates. Adjusted Cohen's d are reported.

Samples included: all seven samples were included. Samples excluded: none. Significance threshold: P<0.00146; i² indicates heterogeneity across studies.