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. 2017 May 9;7(5):e1125. doi: 10.1038/tp.2017.85

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Pdxdc1 knockdown increases PPI but not acoustic startle. All figures show percent change in prepulse inhibition (PPI) from week 2 to 5 after surgery. (a) Surgery and testing timeline from arrival at 9 weeks old until death. (b) Three prepulse intensities (PP69, 73, 81) were tested in every treatment group: one-way ANOVA with each prepulse level showed no significant differences. (c) Combining treatment groups and prepulse intensities showed a significant increase in PPI after Pdxdc1 knockdown (PPIc refers to combined PPI levels for all prepulse intensities and treatment groups; shown is the percent change in PPIc after surgery: **P=0.0025). (d) There was no statistically significant difference in startle response between groups (shown as percentage of startle before surgery). (e) Longitudinal measurement of startle response from week 1–6. Number of mice per group: sham=20, -shRNA=15, V2LMM=20, V3LMM=22. ANOVA, analysis of variance.