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. 2017 May 9;7(5):e1125. doi: 10.1038/tp.2017.85

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Pdxdc1 knockdown increases locomotor activity. (a) Differences in horizontal locomotor activity were seen between sham and V2 groups at 5 min (P<0.05). At 10 min, differences between –shRNA and V3LMM groups (P<0.05) were seen with one-way analysis of variance (ANOVA; F_3,113=2.785, P=0.0441) with Tukey’s HSD. No other significant differences were seen. (b) Horizontal distance moved in the first 5 min was greater in the Pdxdc1 knockdown group. Combined groups: controls vs anti-Pdxdc1: **P=0.0076, unpaired two-tailed Student’s t-test. (c) Total vertical activity was greater in the Pdxdc1 knockdown group. Combined group of controls vs anti-Pdxdc1: *P=0.03, unpaired two-tailed Student’s t-test (sham n=20, −shRNA n=10, V2LMM n=18, V3LMM n=1.