Table 2. Statistical summary for the histaminergic genes of interest in the transcriptome-wide differential expression analysis.

Gene symbol	Log2 fold change	P-value	q-value	Control mean expression	ASD mean expression
HNMT	0.080	0.003	0.245	0.74	0.82
HRH1	0.095	0.072	0.484	0.12	0.22
HRH2	0.029	0.445	0.819	1.01	1.04
HRH3	0.061	0.166	0.626	0.94	1.00

Statistical summary of the histamineric genes of interest that were sufficiently expressed for differential expression analysis between autism spectrum disorder (ASD) and control subjects in the dorsolateral prefrontal cortex. Log fold change is indicated with the controls as the reference group; therefore, each of these genes is more highly expressed in ASD subjects than in control subjects. The P-value indicates the nominal significance for each gene in the differential expression analysis. The q-value indicates the multiple testing corrected significance value for each gene. Mean expression is expressed as log2(RPKM+1) values and reflect correction of confounding effects by principal components.