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. 2017 May 16;7(5):e1128. doi: 10.1038/tp.2017.95

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Production of BDNF and BDNF pro-peptide from its precursor. The human BDNF gene produces preproBDNF protein, which is processed to proBDNF (~32 kDa). Following cleavage of the signal peptide, proBDNF (~32 kDa) is converted to BDNF mature form (~13 kDa) and BDNF pro-peptide (~17 kDa) by intracellular and extracellular proteases. Mature BDNF preferentially binds the TrkB receptor, while proBDNF and BDNF pro-peptide bind to p75^NTR. BDNF, brain-derived neurotrophic factor; TrkB, tropomyosin-related kinase B.