Table 2.
The Clinical Functional Response of the Patient to Baseline (AAI) and Biventricular (DDD‐BiV) Pacing was Recorded at Time of Implant (ACUTE) and After at Least 6 Months of Sustained Pacing (CHRONIC)
| Case | Time | Clinical AHR | Simulated AHR |
|---|---|---|---|
| Case 1 | ACUTE | 34.2% | 30.1% |
| CHRONIC | 18.9% | 18.1% | |
| Case 2 | ACUTE | 17.8% | 16.1% |
| CHRONIC | 19.2% | 19.7% | |
| Case 3 | ACUTE | 0.3% | 6.1% |
| CHRONIC | 23.0% | 20.5% |
The pacing lead locations were mapped onto personalized biophysically based models of the heart for 3 patients. The heart models were used to simulate AAI and DDD‐BiV pacing at the ACUTE and CHRONIC points. The acute hemodynamic response (AHR) of the heart to pacing was calculated as the relative change in the maximal change in left ventricular pressure over time between DDD‐BiV and AAI pacing. The simulated AHR shows good agreement with the clinical AHR at both the ACUTE and CHRONIC time points.