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WFS1 variant distribution based on disease phenotype. Position of the amino acid involved in the disease phenotype is indicated by different shades. Position of the transmembrane regions were predicted based on TMHMM (Krogh, Larsson, von Heijne, & Sonnhammer, 2001) and SMART (Letunic, Doerks, & Bork, 2015). ER, endoplasmic reticulum
