Skip to main content
. 2017 Jun 5;292(30):12516–12527. doi: 10.1074/jbc.M117.788992

Figure 2.

Figure 2.

Structural and BMP-2-binding epitope comparisons among vWC domains. A–C, overlays of the Col2a (purple) and CCN3 (red), Col2a (purple) and CV-2 (turquoise, PDB entry 3BK3), and CCN3 (red) and CV-2 (turquoise) vWCs, respectively, with insets show 90° rotated views of each of the three major structural features. D, overlay of the three vWC domains, with a zoomed-in inset highlighting the disulfide bonds that link SD1 and SD2. E, structure of BMP-2 (gray with semi-transparent surface) in complex with vWC domain from CV-2 (turquoise). The insets show overlays of Col2a vWC SD1 and CCN3 vWC SD1 with CV-2 vWC1 SD1 bound to BMP-2 (gray). Residues in CV-2 involved in BMP-2 binding are shown as sticks.