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AXP/CBS interaction network in human AMPK-γ1. Shown are the three AMP-bound CBS sites in holo-AMPK co-crystallized with AMP. β- and γ-phosphate interacting residues (gray) are collectively based on the structures of core AMPK co-crystallized with ATP (PDB code 4EAG) (20) and core- AMPK soaked with ATP (PDB codes 2V92 and 4EAJ) (19, 20).
