Figure 3.

Epidermal growth factor receptor (EGFR) inhibition reduces significantly gamma-toxin-induced IL-8 production in HVECs. HVECs were exposed to HlgAB (50 µg/mL) or HlgCB (100 µg/mL) at a 1:1 molar ratio for 6 h and IL-8 production was analyzed by ELISA. IL-8 production in response to HlgAB or HlgCB was attenuated in the presence of (A,B) AG1478 or (C,D) UO126. Data show mean +/− standard deviation. Asterisks indicate significant difference from gamma-toxin treated cells with no inhibitor present (p < 0.05).