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ADAM inhibition reduces HlgAB-induced IL-8 production in HVECs. HVECs were exposed to HlgAB (50 µg/mL) or HlgCB (100 µg/mL) at a 1:1 molar ratio for 6 h and processed for IL-8 production by ELISA. TAPI-1 treatment reduced IL-8 production in response to (A) HlgAB but not (B) HlgCB. Data show mean +/− standard deviation. Asterisks indicate significant difference from gamma-toxin-treated cells with no inhibitor present (p < 0.05).
