Table 2.
In vitro results of conjugates of ibuprofen against different tumor cell lines and normal HGF fibroblasts expressed as IC50 in μM.
| Cell Line/(μM ± SD) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Sample | U251 | PC-3 | K-562 | HCT-15 | MFC-7 | SKLU-1 | MDA | HGF |
| 1 | 3.1 ± 0.1 | 19.9 ± 1.5 | 7.3 ± 0.6 | 11.0 ± 0.7 | 4.2 ± 0.3 | 3.6 ± 0.4 | 6.8 ± 0.9 | 32.3 ± 4.3 |
| 2 | 6.7 ± 0.6 | 15.9 ± 1.4 | 3.4 ± 0.8 | 11.3 ± 0.7 | 7.9 ± 0.7 | 12.9 ± 1.1 | 3.6 ± 1.5 | 22.3 ± 4.3 |
| 3 | 3.3 ± 0.2 | 4.4 ± 0.3 | 5.2 ± 0.5 | 5.9 ± 0.2 | 5.5 ± 0.4 | 5.9 ± 0.1 | 4.3 ± 0.4 | 20.3 ± 4.3 |
| 4 | 3.5 ± 0.5 | 11.4 ± 0.2 | 3.0 ± 0.5 | 6.3 ± 0.4 | 3.3 ± 0.3 | 4.2 ± 0.7 | 3.1 ± 0.5 | Not active |
| Cisplatin | 10.8 ± 0.7 | 17.5 ± 1.4 | 1.2 ± 0.08 | 12.3 ± 0.8 | 17.4 ± 0.8 | 12.2 ± 0.9 | 11.2 ± 0.9 | 12.2 ± 0.9 |
IC50 values are presented as the mean ± SD (standard deviation) from five separate experiments.