Table 3.

Calculation of the benefit-harm metric at 24 months follow-up

Outcome	Number of outcomes if 1000 patients were treated		Number of outcomes caused or prevented by implant therapy (NX = NX,SYS - NX,IMP)*	Weight assigned to the outcome (WX)	NX * WX
	Treated with implant therapy (NX,IMP)	Treated with systemic therapy (NX,SYS)
Visual acuity of the better-seeing eyes remained at worse than 20/40 or decreased to worse than 20/40	280	211	−69	0.8	−55
Incident glaucoma†	226	60	−166	0.7	−116
Requiring cataract surgery	612	252	−359	0.6	−216
Requiring glaucoma surgery	331	67	−263	0.6	−158
Incident cataracts‡	173	86	−87	0.3	−26
Prescription-requiring hypertension	41	76	34	0.3	10
Prescription-requiring hyperlipidemia	25	67	42	0.3	13
Prescription-requiring infections	369	479	110	0.2	22
Benefit-harm metric (IX)					−526

^*Numbers of outcomes caused are negative and numbers of outcomes prevented are positive.

^†Assuming 97% of patients at risk at baseline.

^‡Assuming 18% of patients at risk at baseline.