Table 5.
Univariable and Multivariable Cox Regression Analyses Predicting OS in 240 Patients with gastric cancer
| Parameters | Median OS | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95%CI) | P | HR(95%CI) | P value | ||
| Ages,years | |||||
| ≤59 | 16.7 (14.0-19.5) | referent | - | ||
| >59 | 14.0 (11.3-16.6) | 1.058 (0.819-1.365) | 0.667 | ||
| Gender | |||||
| Female | 15.6 (13.3-17.9) | referent | - | ||
| Male | 15.1(12.7-17.5) | 1.094 (0.828-1.444) | 0.527 | ||
| Stage | |||||
| Ⅰ-Ⅱ | 23.9 (17.6-30.2) | referent | - | referent | - |
| Ⅲ-Ⅳ | 14.2 (12.7-15.8) | 1.556 (1.119-2.165) | 0.009 | 1.339(0.955-1.878) | 0.080 |
| Differentiation | |||||
| Poor | 14.4 (12.7-16.1) | referent | - | ||
| Well | 17.7 (11.8-23.6) | 0.795(0.601-1.052) | 0.109 | ||
| Tumor PD-L1 | |||||
| Negative | 19.52(15.49-23.55) | referent | - | - | |
| Positive | 19.31(16.93-21.68) | 0.991(0.740-1.328) | 0.954 | ||
| TIL PD-L1 | |||||
| Negative | 18.3(14.0-22.5) | referent | - | referent | - |
| Positive | 14.2(11.8-16.6) | 1.622(1.229-2.140) | 0.001 | 1.502(1.130-1.995) | 0.005 |
| Surgery | |||||
| No | 10.0(5.4-14.5) | referent | - | referent | - |
| Yes | 16.1 (14.0-18.1) | 0.481(0.341-0.678) | <0.001 | 0.516(0.365-0.730) | <0.001 |
| Tumor location | |||||
| Proximal | 15.6 (11.8-19.4) | ||||
| Remote | 15.4 (12.7-18.2) | ||||
| Body | 14.9 (12.9-16.9) | referent | |||
| other | 15.3 (4.5-26.2) | 1.079(0.947-1.230) | 0.253 | ||
Abbreviations: OS, overall survival; HR, hazard ratio;TIL:tumor infiltration lymphocyte