Table 2.

Anticancer drugs in the regulation of ROS levels

Name	Mechanism of action	Effects on ROS	Cancers	Refs
5-Fu	Inhibits thymidylate synthetase and/or incorporates into RNA and DNA	Induces intracellular increase in O2•- levels	CRC	[137]
Tamoxifen	Promotes cancer cell senescence	Promotes ROS generation	CRC	[159]
Celecoxib	Inhibits COX2 activity, Induces ER stress by causing leakage of calcium from the ER into the cytosol	Induction of ROS owing to ER stress	CRC	[150]
Methotrexate	Triggers ROS related cell apoptosis	Promotes ROS generation	Different types of cancer	[160]
Irinotecan	Topoisomerases inhibitor	Promotes ROS generation	Different types of cancer	[161]
Mitoxantrone	Trigging cell membrane scrambling	Promotes ROS generation	Different types of cancer	[162]
Paclitxel(Taxol)	Inhibitor of cell division	Promotes ROS generation	Different types of cancer	[163]
Adriamycin	Reduces cell viability through initiating cell apoptosis and strong G2/M phase cell cycle arrest	Promotes ROS generation	Different types of cancer	[164]
Imatinib	Protein tyrosine kinase inhibitor that induce apoptosis	Promotes ROS generation	Different types of cancer	[165]
Camptothecin	Quinolone alkaloid that induces cytotoxicity	Promotes ROS generation	Different types of cancer	[166]
Carboplatin	Cell cycle arrest	Induction of ROS owing to ER stress	Different types of cancer	[167]
Capecitabine	Prodrug that is enzymatically converted to 5-Fu in the body	Promotes ROS generation	CRC	[168]
Cisplatin	Inducing nuclear DNA adducts	Induces a mitochondrial dependent ROS generation	Different types of cancer	[169]
Manumycin	Increasing the ROS production and blocking PI3K/AKT pathway	Promotes ROS generation	CRC	[170]
Cribrostatin 6	Quinone containing product induces apoptotic cell death	Promotes ROS generation	Different types of cancer	[171]