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. Author manuscript; available in PMC: 2017 Jul 31.
Published in final edited form as: JAMA Cardiol. 2016 May 1;1(2):163–171. doi: 10.1001/jamacardio.2016.0008

Figure 2. Effects of Intracoronary Administration of Adenovirus 5 Encoding Adenylyl Cyclase 6 on Left Ventricular (LV) Ejection Fraction (EF) and Exercise Duration.

Figure 2

A, Placebo participants (baseline, n = 14; 4 and 12 weeks, n = 13) did not show significantly increased EF at 4 weeks (mean [SE] +4.1 [2.2] EF units; P = .08) or at 12 weeks (+0.8 [1.2] EF units; P = .48). Dose 4 and 5 (D4 + 5) participants (baseline, n = 23; 4 and 12 weeks, n = 21) showed increased EF at 4 weeks (+5.5 [1.7] EF units; P < .004) but less increase at 12 weeks (+3.5 [2.3] EF units; P = .16). Between-group findings for D4 + 5 and placebo were not significant (4 weeks, P = .59; 12 weeks, P = .42). B, Placebo participants (baseline, n = 14; 4 weeks, n = 13; 12 weeks, n = 12) did not have increased exercise treadmill test (ETT) duration at 4 weeks, but did at 12 weeks (P = .03). D4 + 5 participants (baseline, n = 19; 4 and 12 weeks, n = 17) showed no significant increases in ETT duration at 4 weeks (P = .10) or 12 weeks (P = .06). Error bars denote SE. Between-group findings for D4 + 5 and placebo were not significant (4 weeks, P = .70; 12 weeks, P = .94). AC6 indicates adenylyl cyclase 6.