Figure 5.

Effect of Antrocaryon micraster extract on carrageenan-induced paw oedema in mice. Oedema was induced and monitored as described in the Methods. Percentage increase in paw thickness (a and c) and total oedema induced during the 6 h was calculated as area under the time course curves, AUC (b and d). Drug vehicle, AME 30–300 mg/kg, and diclofenac 100 mg/kg were given in the prophylactic (top panel) or curative protocol (bottom panel). Data is presented as mean ± SEM (n = 5). ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001 compared to vehicle-treated group (one-way ANOVA followed by Dunnett's post hoc test). Arrow indicates point of extract administration in the curative protocol.