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. Author manuscript; available in PMC: 2017 Nov 9.
Published in final edited form as: J Am Chem Soc. 2016 Nov 1;138(44):14554–14557. doi: 10.1021/jacs.6b09653

Table 3.

Scope of Alkyl Aminesa,b

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a

Conditions: 1c–o (0.2 mmol), 4-CO2MePhI (0.4 mmol), Pd(OAc)2 (10 mol%), TDG4 (20 mol%), AgTFA (0.4 mmol), HFIP/HOAc = 19/1 (1.0 mL), H2O (2.0 mmol), 120 °C, 12 h.

b

Isolated yields.

c

90 °C.

d

50 mol% TDG4.

e

150 °C, HFIP/HOAc = 2:1, 30 eq H2O.