Scheme 2.

Diversifiations of Brominated Products^a

^a Conditions: (a) NaCN (2.0 equiv), THP (tetrahydropyran), 80 °C, 24 h; (b) NaN₃ (4.0 equiv), MeOH, 40 °C, 24 h; (c) pyrrolidine (2.0 equiv), K₂CO₃ (1.5 equiv), THF, r.t., 1 h; (d) Bn₂NH (2.0 equiv), K₂CO₃ (1.5 equiv), THF, 80 °C, 24 h; (e) AgNO₃ (2.0 equiv), EtOAc, 80 °C, 24 h; (f) PhSH (2.0 equiv), NaOH (2.0 equiv), EtOH, 40 °C, 1 h; (g) NaCN (2.0 equiv), THF, 80 °C, 24 h; (h) morpholine (2.0 equiv), K₂CO₃ (1.5 equiv), THF, r.t., 1 h.