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. Author manuscript; available in PMC: 2018 Apr 26.
Published in final edited form as: J Am Chem Soc. 2017 Apr 13;139(16):5724–5727. doi: 10.1021/jacs.7b02196

Table 1.

Ligand Screening for C(sp3)–H Bromination a,b

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a

Conditions: 0.1 mmol of 1a, 2.0 equiv of NBS, 10 mol% of Pd(OAc)2, 10 mol% of ligand, 1.5 equiv of PhI(OAc)2, 1.0 mL of DCE, 80 °C, under air, 20 h.

b

The yield was determined by 1H NMR analysis of the crude product using CH2Br2 as the internal standard.

c

Optimal conditions: 0.1 mmol of 1a, 1.75 equiv of NBS, 10 mol% of Pd(OAc)2, 10 mol% of ligand L6, 1.5 equiv of PhI(OAc)2, 5.0 equiv of AcOH, 1.0 mL of DCE, 70 °C, under air, 20 h.