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. Author manuscript; available in PMC: 2018 Apr 26.
Published in final edited form as: J Am Chem Soc. 2017 Apr 13;139(16):5724–5727. doi: 10.1021/jacs.7b02196

Table 3.

C(sp3)–H Bromination and Iodination of Carboxylic Acid Derivativesa,b,c

graphic file with name nihms877174f6.jpg
a

Bromination conditions: 0.1 mmol of 1a, 1.75 equiv of NBS, 10 mol% of Pd(OAc)2, 10 mol% of ligand L6, 1.5 equiv of PhI(OAc)2, 5.0 equiv of AcOH, 1.0 mL of DCE, 70 °C, under air, 20 h.

b

Iodination conditions: 0.1 mmol of 1a, 1.5 equiv of I2, 1.5 equiv of PhI(OAc)2, 10 mol% of Pd(OAc)2, 10 mol% of ligand L17, 1.0 equiv of AcOH, 0.8 mL of 1,4-dioxane, 0.2 mL of DCE, 80 °C, under air, 20 h.

c

Isolated yields.

d

2.0 mmol scale.