Table 3.
Variables significantly associated with malnutrition in univariate analysis
| Instrument | Number of subjects (% malnourished) | P-value | |
|---|---|---|---|
| Categorical variables | |||
| Global NIH Score | 1 = 4 (0%), 2 = 68 (15%), 3 = 137 (37%) | 0.0006 | |
| Joints and fascia NIH Score | 0 = 81 (22%), 1 = 47 (28%), 2 = 60 (30%), 3 = 21 (52%) | 0.02 | |
| Lungs NIH Score | 0 = 48 (12%), 1 = 87 (25%), 2 = 51 (33%), 3 = 21 (71%) | < 0.0001 | |
| Gl tract NIH Score | 0 = 117 (15%), 1 = 69 (33%), 2 = 16 (88%), 3 = 7 (86%) | < 0.0001 | |
| Mouth NIH Score | 0 = 65 (17%), 1 = 115 (28%), 2 = 23 (52%), 3 = 6 (83%) | < 0.0001 | |
| Physician global rating of cGVHD activity | 1 = 38 (11%), 2 = 67 (25%), 3 = 67 (45%) | 0.0002 | |
| Instrument | Well-nourished (mean ± s.e.m.) | Malnourished (mean ± s.e.m.) | P-value |
|
| |||
| Continuous variables | |||
| Lines of prior systemic therapy for cGVHD | 3.43 ± 0.16 | 4.23 ± 0.26 | 0.01 |
| NIH Average Score | 0.96 ± 0.03 | 1.28 ± 0.05 | < 0.0001 |
| Lee total Scorea | 32.78 ± 1.33 | 42.74 ± 2.09 | < 0.0001 |
| SF-36 physical health summaryb | 38.04 ± 0.86 | 31.06 ± 1.56 | < 0.0001 |
| FACT-BMT physical well-beingc | 19.30 ± 0.53 | 17.22 ± 0.82 | 0.02 |
| FACT-BMT functional well-beingc | 17.35 ± 0.54 | 13.79 ± 0.86 | 0.0006 |
| HAP, Maximum Activity Score (MAS)d | 73.93 ± 1.09 | 63.24 ± 2.29 | 0.0001 |
| HAP, Adjusted Activity Score (AAS)d | 63.08 ± 1.40 | 49.69 ± 2.86 | < 0.0001 |
| Albumin | 3.66 ± 0.04 | 3.45 ± 0.06 | 0.004 |
| BMI (kg/m2) | 26.17 ± 034 | 20.84 ± 0.62 | < 0.0001 |
Abbreviations: cGVHD = chronic GVHD; FACT-BMT = Functional Assessment of Cancer Therapy-Bone Marrow Transplant; HAP = Human Activity Profile; NIH = National Institutes of Health; SF-36 = Short-Form 36 Health Survey.
The Lee cGVHD Symptom Scale is a patient-reported questionnaire with seven subscales (skin, eyes and mouth, breathing, eating and digestion, muscles and joints, energy, mental and emotional) designed to capture cGVHD-specific symptom burden.
The FACT-BMT, is a patient-reported questionnaire concerning BM-related quality-of-life issues. It has four domains (physical well-being, social/family well-being, emotional well-being and functional well-being).
The SF-36 Health Survey is a patient-reported questionnaire concerning health quality-of-life issues. It has eight sections (physical functioning, bodily pain, general health perceptions, physical role functioning, vitality, emotional role functioning, social role functioning and mental health). The first four sections are combined as a Physical Health Summary, and the second four sections are combined as a Mental Health Summary.
The HAP is a patient-reported questionnaire of energy expenditure or physical fitness.