Table 2.

Genotype and Allelic Frequencies for Transport, Metabolism, and Regulatory Genes Relevant to Cisplatin Disposition (n = 206).

Gene	Variant	Homozygous Wildtype Frequency Observed		Heterozygous Frequency Observed		Homozygous Variant Frequency Observed		Undeter-Mined	Major Allele Frequency Observed (Expected)		Minor Allele Frequency Observed (Expected)
SLC22A2 (OCT2)	rs316019 *	C/C	0.679	A/C	0.187	A/A	0.014	0.120	C	0.824 (0.79)	A	0.118 (0.21)
	rs3127573	A/A	0.737	A/G	0.211	G/G	0.010	0.043	A	0.858 (0.88)	G	0.10 (0.12)
	rs2279463	A/A	0.665	A/G	0.201	G/G	0.005	0.014	A	0.869 (0.88)	G	0.097 (0.12)
	rs596881	C/C	0.741	C/T	0.230	T/T	0.010	0.019	C	0.861 (0.89)	T	0.098 (0.11)
SLC31A1 (CTR1)	rs7851395	A/A	0.306	A/G	0.431	G/G	0.187	0.077	A	0.553 (0.53)	G	0.431 (0.47)
	rs12686377	C/C	0.718	A/C	0.158	A/A	0.038	0.086	C	0.847 (0.92)	A	0.194 (0.08)
SLC47A1 (MATE1)	rs2289669	G/G	0.278	A/G	0.464	A/A	0.196	0.062	G	0.527 (0.54)	A	0.443 (0.46)
ABCC2 (MRP2)	rs717620	C/C	0.603	C/T	0.258	T/T	0.043	0.096	C	0.776 (0.81)	T	0.207 (0.19)
	rs2273697 *	G/G	0.531	A/G	0.325	A/A	0.053	0.091	G	0.729 (0.82)	A	0.23 (0.18)
	rs3740066	C/C	0.397	C/T	0.368	T/T	0.144	0.091	C	0.63(0.62)	T	0.379 (0.38)
GGT1	rs4820599	A/A	0.464	A/G	0.349	G/G	0.100	0.086	A	0.681 (0.73)	G	0.316 (0.27)
GSTP1	rs1695 *	A/A	0.354	A/G	0.402	G/G	0.129	0.033	A	0.63(0.59)	G	0.372 (0.41)
KEAP1	rs11085735	C/C	0.746	A/C	0.139	A/A	0.014	0.100	C	0.864 (0.91)	A	0.118 (0.09)
	rs1048290	C/C	0.282	C/G	0.407	G/G	0.129	0.182	C	0.531 (0.68)	G	0.359 (0.32)
NFE2L2 (NRF2)	rs2886162	A/A	0.239	A/G	0.459	G/G	0.220	0.081	A	0.489 (0.58)	G	0.469 (0.42)
	rs1806649	C/C	0.512	C/T	0.311	T/T	0.053	0.124	C	0.716 (0.77)	T	0.23 (0.23)
	rs1962142	G/G	0.000	A/G	0.670	A/A	0.244	0.086	G	0(0.92)	A	0.494 (0.08)
	rs2706110	C/C	0.560	C/T	0.344	T/T	0.086	0.010	C	0.748 (0.8)	T	0.293 (0.2)
	rs6721961	G/G	0.665	G/T	0.225	T/T	0.024	0.091	G	0.815 (0.8)	T	0.155 (0.2)

* Denotes non-synonymous variant.