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. 2017 Jun 23;18(7):1348. doi: 10.3390/ijms18071348

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of RUNX1 on the bone morphogenetic protein 9 (BMP9)-induced early osteogenic differentiation of MSCs and MMCs. Cells were infected with Ad-RUNX1 or Ad-siRUNX1, followed by treatment with optimal BMP9-CM. ALP activity was detected by histochemical staining assay and chemiluminescence assay at five days(5D)and seven days(7D).Overexpression of RUNX1 promoted BMP9-induced ALP activity in: C3H10T1/2 (A–C); C2C12 (D–F); and MEFs (G–I). Inhibition of RUNX1 decreased BMP9-induced ALP activity in: C2C12 (J–L); and MEFs (M–O). ** p < 0.01, as compared with BMP9 group.