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Effect of RUNX1 on BMP9-induced late osteogenic differentiation of MSCs and MMCs. Cells were infected with Ad-RUNX1or Ad-siRUNX1, followed by treatment with optimal BMP9-CM. Matrix mineralization was assessed at 14 days post-treatment by Alizarin Red S staining. Overexpression of RUNX1 promoted BMP9-induced calcium deposition in: C3H10T1/2(A); C2C12 (B); and MEFs (C). Inhibition of RUNX1 decreased BMP9-induced calcium deposition in: C2C12 (D); and MEFs (E). Magnification, ×100.
