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. 2017 Jun 23;18(7):1348. doi: 10.3390/ijms18071348

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of RUNX1 on BMP9-induced mRNA expression levels of pivotal osteogenic markers. Cells were infected with Ad-RUNX1 or Ad-siRUNX1, and then treated by optimal BMP9-CM.Total RNA was extracted from the cultures and was measured by RT-qPCR. Overexpression of RUNX1 promoted BMP9-induced mRNA levels of DLX5 (Distal-less homeobox 5) (A); RUNX2 (B); CollaI (C); and OSX (D), in C3H10T1/2, C2C12 and MEFs. (E) Overexpression of RUNX1 promoted BMP9-induced mRNA levels of OCN in MEFs. Inhibition of RUNX1 decreased BMP9-induced mRNA levels of: DLX5 (F); RUNX2 (G); CollaI (H); and OSX (I) in C2C12 and MEFs. (J) Inhibition of RUNX1 decreased BMP9-induced mRNA levels of OCN in MEFs. * p < 0.05, as compared with BMP9 group.