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. 2017 Jun 23;18(7):1348. doi: 10.3390/ijms18071348

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of RUNX1 on BMP9-induced protein expression levels of pivotal osteogenic markers. Cells were infected with Ad-RUNX1 or Ad-siRUNX1, and then treated by optimal BMP9-CM. Total protein was extracted and was measured by Western blot. (A) Overexpression of RUNX1 promoted the expression of BMP9 induced OCN in protein levels, while its deficiency using Ad-RUNX1 reduced OCN expression. Overexpression of RUNX1 promoted BMP9-induced protein expression levels of DLX5 and RUNX2 in: C3H10T1/2 (B); C2C12 (C); and MEFs (D). Inhibition of RUNX1 decreased BMP9-induced protein expression of DLX5 and RUNX2 in: C2C12 (E); and MEFs (F). * p < 0.05, as compared with BMP9 group.