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. 2017 Jun 24;18(7):1355. doi: 10.3390/ijms18071355

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Gene Ontology (GO)/KEGG pathway analysis and K-means clustering analysis of hippocampus proteins with significantly altered expression. (A) GO annotation and enrichment of the hippocampus proteins with significantly altered expression in part one; (B) GO annotation and enrichment of the hippocampus proteins with significantly altered expression in part two; (C) clustering of significant altered hippocampus proteins of part one, and the two major clusters extracted by K-means clustering for the next analysis; (D) clustering of significantly altered hippocampus proteins of part two, and the two major clusters extracted by K-means clustering for the next analysis; (E) the enriched biological pathways in these two major clusters of significantly altered proteins in part one, as viewed by KEGG pathway analysis; (F) KEGG pathway analysis of only enriched pathways related to signal transduction and environment for these significantly altered proteins of part two.

Gene Ontology (GO)/KEGG pathway analysis and K-means clustering analysis of hippocampus proteins with significantly altered expression. (A) GO annotation and enrichment of the hippocampus proteins with significantly altered expression in part one; (B) GO annotation and enrichment of the hippocampus proteins with significantly altered expression in part two; (C) clustering of significant altered hippocampus proteins of part one, and the two major clusters extracted by K-means clustering for the next analysis; (D) clustering of significantly altered hippocampus proteins of part two, and the two major clusters extracted by K-means clustering for the next analysis; (E) the enriched biological pathways in these two major clusters of significantly altered proteins in part one, as viewed by KEGG pathway analysis; (F) KEGG pathway analysis of only enriched pathways related to signal transduction and environment for these significantly altered proteins of part two.