Table 4.
Associations between HLA-G 3′UTR SNPs and G3-4 neutropenia toxicity.
| HLA-G 3′UTR SNP | SNP ID | Alleles | Genotypes | n | Most Significant Genetic Model | Bootstrap | ||
|---|---|---|---|---|---|---|---|---|
| Model | OR (95% CI) a | p | p | |||||
| +14-bp INDEL | rs371194629 | Del | Del/Del | 13 | Rec | 1.81 (0.80–4.09) | 0.154 | |
| Ins | Del/Ins | 25 | ||||||
| Ins/ins | 15 | |||||||
| +3003 T>C | rs1707 | T | T/T | 48 | Dom | 0.37 (0.13–1.08) | 0.068 | |
| C | T/C | 4 | ||||||
| C/C | 1 | |||||||
| +3010 C>G | rs1710 | C | C/C | 22 | Dom | 0.73 (0.36–1.48) | 0.389 | |
| G | C/G | 25 | ||||||
| G/G | 6 | |||||||
| +3027 C>A | rs17179101 | C | C/C | 46 | Dom | 1.46 (0.49–4.33) | 0.497 | |
| A | C/A | 7 | ||||||
| +3035 C>T | rs17179108 | C | C/C | 41 | Dom | 1.22 (0.51–2.95) | 0.655 | |
| T | C/T | 12 | ||||||
| +3142 G>C | rs1063320 | G | G/G | 22 | Dom | 0.73 (0.36–1.49) | 0.386 | |
| C | G/C | 25 | ||||||
| C/C | 6 | |||||||
| +3187 A>G | rs9380142 | A | A/A | 30 | Rec | 0.51 (0.10–2.67) | 0.423 | |
| G | A/G | 21 | ||||||
| G/G | 2 | |||||||
| +3196 C>G | rs1610696 | C | C/C | 21 | Rec | 3.76 (1.29–10.96) | 0.015 | 0.042 |
| G | C/G | 21 | ||||||
| G/G | 11 | |||||||
Significant associations are reported in bold (p < 0.05); a Estimated with a logistic regression model adjusted for sex, age, and neo-adjuvant therapy. HLA-G: human leukocyte antigen-G; 3′UTR: 3′ untranslated region; SNP: Single nucleotide polymorphism; OR: Odds ratio; CI: Confidence Interval; Rec: Recessive; Dom: Dominant.