Table 5.
Associations between HLA-G 3′UTR SNPs and G3-4 neurotoxicity.
| HLA-G 3′UTR SNP | SNP ID | Alleles | Genotypes | n | Most Significant Genetic Model | Bootstrap | ||
|---|---|---|---|---|---|---|---|---|
| Model | OR (95% CI) a | p | p | |||||
| +14-bp INDEL | rs371194629 | Del | Del/Del | 2 | Rec | 5.49 (1.21–24.85) | 0.027 | 0.022 |
| Ins | Del/Ins | 3 | ||||||
| Ins/ins | 5 | |||||||
| +3003 T>C | rs1707 | T | T/T | 10 | Add | 0.00 (0.00–∞) | 0.960 | |
| +3010 C>G | rs1710 | C | C/C | 5 | Dom | 0.53 (0.14–2.04) | 0.357 | |
| G | C/G | 4 | ||||||
| G/G | 1 | |||||||
| +3027 C>A | rs17179101 | C | C/C | 10 | Add | 0.00 (0.00–∞) | 0.970 | |
| +3035 C>T | rs17179108 | C | C/C | 8 | Add | 0.00 (0.00–∞) | 0.985 | |
| T | C/T | 2 | ||||||
| +3142 G>C | rs1063320 | G | G/G | 5 | Dom | 0.53 (0.14–2.04) | 0.357 | |
| C | G/C | 4 | ||||||
| C/C | 1 | |||||||
| +3187 A>G | rs9380142 | A | A/A | 5 | Add | 1.37 (0.48–3.91) | 0.556 | |
| G | A/G | 4 | ||||||
| G/G | 1 | |||||||
| +3196 C>G | rs1610696 | C | C/C | 3 | Rec | 8.78 (1.50–51.44) | 0.016 | 0.019 |
| G | C/G | 3 | ||||||
| G/G | 4 | |||||||
Significant associations are reported in bold (p < 0.05); a Estimated with a logistic regression model adjusted for sex, age, and neo-adjuvant therapy. HLA-G: Human leukocyte antigen-G; 3′UTR: 3′ untranslated region; SNP: Single nucleotide polymorphism; OR: Odds ratio; CI: Confidence Interval; Rec: Recessive; Add: Additive; Dom: Dominant.