Table 6.
Significant associations between HLA-G 3′UTR haplotypes and G3-4 toxicities.
| Toxicity Type | Haplotype | 14-bp | +3003 | +3010 | +3027 | +3035 | +3142 | +3187 | +3196 | n | Significant Genetic Models | Bootstrap | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model | OR (95%-CI) a | p | p | |||||||||||
| Hematological | UTR-2 | Ins | T | C | C | C | G | A | G | Rec | 3.46 (1.14–11.52) | 0.028 | 0.078 | |
| Het | 23 | |||||||||||||
| Hom | 10 | |||||||||||||
| Hematological | UTR-4 | Del | C | G | C | C | C | A | C | Dom | 0.35 (0.12–0.98) | 0.046 | 0.098 | |
| Het | 4 | |||||||||||||
| Hom | 1 | |||||||||||||
| Neutropenia | UTR-2 | Ins | T | C | C | C | G | A | G | Rec | 3.92 (1.28–12.07) | 0.017 | 0.059 | |
| Het | 22 | |||||||||||||
| Hom | 10 | |||||||||||||
| Neutropenia | UTR-6 | Del | T | G | C | C | C | A | C | Dom | 4.77 (1.07–21.20) | 0.040 | 0.058 | |
| Het | 6 | |||||||||||||
| Hom | 0 | |||||||||||||
| Neurotoxicity | UTR-2 | Ins | T | C | C | C | G | A | G | Rec | 11.29 (1.84–69.40) | 0.009 | 0.019 | |
| Het | 3 | |||||||||||||
| Hom | 4 | |||||||||||||
Significant associations are reported in bold (p < 0.05); a Estimated with a logistic regression model adjusted for sex, age, neo-adjuvant therapy, and the oxaliplatin cumulative dose, normalized with body surface area (BSA), for neurological toxicity. HLA-G: Human leukocyte antigen-G; 3′UTR: 3′ Untranslated region; OR: Odds ratio; CI: Confidence interval; Het: Heterozygous; Hom: Homozygous; Rec: Recessive; Dom: Dominant.