Figure 11.

Steric (A) and electrostatic (B) contour maps obtained using CoMFA-derived models based on molecule 2. Green regions (A) indicates regions where the introduction of a bulky group would increase activity. Yellow regions (A) indicates regions where the introduction of a bulky group would decrease activity. Red regions (B) indicates regions where the introduction of electronegative groups is favored. Blue regions (B) indicates regions where the introduction of electropositive groups is favored. The others in Figure A and B represent the compound 2 (Red, oxygen atoms; yellow and blue, nitrogen atom; cyan, hydrogen atom; gray, carbon atoms).