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Voluntary locomotor activity. The graphs summarize: the number of spontaneous bouts (A); and the distance travelled expressed in meters (B) of all experimental groups, evaluated during 1 h of spontaneous locomotor activity. ANOVA, two-way analysis of variance; * p ≤ 0.05 vs. Reserpine four days; # p ≤ 0.05 vs. Reserpine plus tap water; + p ≤ 0.05 vs. Reserpine plus melatonin 5 mg/kg/day for 2 months and ° p ≤ 0.05 vs. Controls. H2O: tap water; MEL: melatonin; Res: reserpine.
