Figure 3.

Prolonged endotoxemia induces resistance to the hypophagic effect of icv insulin treatment. Effect of icv injection of vehicle (saline, 5 μL) or insulin (12 μM in 5 μL) on food intake (A) and body weight gain (B) in saline (6 saline), single (5 saline + 1 LPS, 100 ug/kg ip), or repeated LPS (6 LPS) treated-animals (6–8 animals per group). The representative results of two independent experiments (n = 6–8/group) are shown. Two-way ANOVA, followed by the Fisher post hoc test were performed. Data are expressed as means ± SE. Differences were accepted as significant at * p < 0.05.